Parkinson's disease and translational research

Research output: Contribution to journalReview articleContributedpeer-review



Parkinson's disease (PD) is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity, and when these symptoms respond to dopaminergic medications. Yet in the last years there was a greater recognition of additional aspects of the disease including non-motor symptoms and prodromal states with associated pathology in various regions of the nervous system. In this review we discuss current concepts of two major alterations found during the course of the disease: cytoplasmic aggregates of the protein α-synuclein and the degeneration of dopaminergic neurons. We provide an overview of new approaches in this field based on current concepts and latest literature. In many areas, translational research on PD has advanced the understanding of the disease but there is still a need for more effective therapeutic options based on the insights into the basic biological phenomena.


Original languageEnglish
Article number43
JournalTranslational neurodegeneration
Issue number1
Publication statusPublished - 1 Dec 2020

External IDs

PubMedCentral PMC7708097
Scopus 85096923179
ORCID /0000-0002-2387-526X/work/150328963



  • Dopamine/metabolism, Dopaminergic Neurons/metabolism, Humans, Parkinson Disease/diagnosis, Prodromal Symptoms, Translational Research, Biomedical/methods, alpha-Synuclein/metabolism