Parental occupational exposures prior to conception and offspring wheeze and eczema during first year of life

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Felix Forster - , Ludwig Maximilian University of Munich (Author)
  • Christian Heumann - , Ludwig Maximilian University of Munich (Author)
  • Bianca Schaub - , Ludwig Maximilian University of Munich, German Center for Lung Research (DZL) (Author)
  • Andreas Böck - , Ludwig Maximilian University of Munich (Author)
  • Dennis Nowak - , Ludwig Maximilian University of Munich, German Center for Lung Research (DZL) (Author)
  • Christian Vogelberg - , Department of Paediatrics, University Hospital Carl Gustav Carus Dresden, TUD Dresden University of Technology (Author)
  • Katja Radon - , Ludwig Maximilian University of Munich, German Center for Lung Research (DZL) (Author)

Abstract

Purpose: Parental exposures prior to conception might influence asthma and allergy risk in offspring. As occupational exposures are established risk factors for asthma and allergies, we investigated if parental occupational exposures prior to conception cause wheeze and eczema in offspring during the first year of life. Methods: We analysed data of 436 families from an offspring cohort based on a follow-up study of German participants of the International Study of Asthma and Allergies in Childhood (ISAAC). Offspring cohort data was collected between 2009 and 2019. Occupational exposures were based on participants’ work histories and measured by a Job-Exposure-Matrix. We used Bayesian logistic regression models for analysis. Inference and confounder selection were based on directed acyclic graphs. Results: In mothers, for both allergic and irritative occupational exposures prior to conception suggestive effects on offspring eczema during the first year of life were found (allergens: odds ratio (OR) 1.22, 95% compatibility interval (CI) 0.92–1.57; irritants: OR 1.36, 95% CI 0.99–1.77), while no relation with wheeze was suggested. Conclusions: Our results suggest that reduction of asthma-related occupational exposures might not only reduce the burden of disease for occupationally induced or aggravated asthma and allergies in employees but also in their children.

Details

Original languageEnglish
Pages (from-to)90-97
Number of pages8
Journal Annals of epidemiology
Volume77
Publication statusPublished - Jan 2023
Peer-reviewedYes

External IDs

PubMed 36476404

Keywords

ASJC Scopus subject areas

Keywords

  • Asthma, Dermatitis, atopic, Maternal exposure, Occupational exposure, Paternal exposure, Follow-Up Studies, Eczema/etiology, Humans, Risk Factors, Occupational Exposure/adverse effects, Respiratory Sounds/etiology, Hypersensitivity/etiology, Asthma/etiology, Bayes Theorem, Female, Child