Optical coherence tomography in biomedical research

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

Abstract

Optical coherence tomography (OCT) is a noninvasive, high-resolution, interferometric imaging modality using near-infrared light to acquire cross-sections and three-dimensional images of the subsurface microstructure of biological specimens. Because of rapid improvement of the acquisition speed and axial resolution of OCT over recent years, OCT is becoming increasingly attractive for applications in biomedical research. Therefore, OCT is no longer used solely for structural investigations of biological samples but also for functional examination, making it potentially useful in bioanalytical science. The combination of in vivo structural and functional findings makes it possible to obtain thorough knowledge on basic physiological and pathological processes. Advanced applications, for example, optical biopsy in visceral cavities, have been enabled by combining OCT with established imaging modalities. This report gives an outline of the state of the art and novel trends of innovative OCT approaches in biomedical research in which the main focus is on applications in fundamental research and pre-clinical utilization.

Details

Original languageEnglish
Pages (from-to)2721-2743
Number of pages23
JournalAnalytical and Bioanalytical Chemistry
Volume400
Issue number9
Publication statusPublished - Jul 2011
Peer-reviewedYes

External IDs

Scopus 79958146712
PubMed 21562739
ORCID /0000-0003-0554-2178/work/142249764
ORCID /0009-0008-7642-8608/work/142255290
ORCID /0000-0003-2292-5533/work/142256539

Keywords

ASJC Scopus subject areas

Keywords

  • Application, Biomedical imaging, Instrumentation, Optical coherence tomography