Olfactory function in patients with idiopathic Parkinson's disease: Effects of deep brain stimulation in the subthalamic nucleus

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Decrease of olfactory function in patients with Parkinson's disease (PD) is a well-investigated fact. The present study aimed to investigate olfaction in PD patients with a specific focus on the effects of deep brain stimulation in the subthalamic nucleus. Eleven patients (age 42-67 years) participated in this study. Using the "Sniffin' Sticks", olfactory function was assessed based on butanol odor thresholds and the patients' ability to discriminate odors. Measures were taken with the stimulator being switched ON and OFF, respectively. While deep brain stimulation had no effect on odor thresholds, in hyposmic PD patients odor discrimination was found to be significantly higher during the ON period. This may indicate that deep brain stimulation has a positive effect on the cognitive processing of olfactory information in PD patients.

Details

Original languageEnglish
Pages (from-to)669-676
Number of pages8
JournalJournal of Neural Transmission
Volume112
Issue number5
Early online date27 Oct 2004
Publication statusPublished - May 2005
Peer-reviewedYes

External IDs

researchoutputwizard legacy.publication#7624
researchoutputwizard legacy.publication#4012
Scopus 17844382746
PubMed 15517435
ORCID /0000-0001-9713-0183/work/157319377

Keywords

Sustainable Development Goals

Keywords

  • Age, Deep brain stimulation, Discrimination, Identification, Olfaction, Parkinson's disease, Thresholds