Occupational UV-exposure is a major risk factor for basal cell carcinoma: Results of the population-based case-control study FB-181
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
- Special Clinics Hornheide
- Friedrich Schiller University Jena
- Friedrich-Alexander University Erlangen-Nürnberg
- Johannes Gutenberg University Mainz
- University Osnabruck
- Ruhr University Bochum
- Heidelberg University
- University of Bonn
- Medical Faculty Carl Gustav Carus
- TUD Dresden University of Technology
Abstract
Objective: The aimof this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC). Methods: We undertook a population-based multicenter case-control study. Patients with first incident BCC (n=836) were propensity score matched by age and sex to controls without skin cancer (n=836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models. Results: Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22) occupational UV-exposure. Nonoccupational UVexposure was not independently associated with BCC. Conclusion: Skin cancer prevention strategies should be expanded to the occupational setting.
Details
Original language | English |
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Pages (from-to) | 36-43 |
Number of pages | 8 |
Journal | Journal of occupational and environmental medicine |
Volume | 60 |
Issue number | 1 |
Publication status | Published - 1 Jan 2018 |
Peer-reviewed | Yes |
External IDs
PubMed | 29111985 |
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ORCID | /0000-0002-4411-3088/work/141543492 |