Occupational UV-exposure is a major risk factor for basal cell carcinoma: Results of the population-based case-control study FB-181

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Special Clinics Hornheide
  • Friedrich Schiller University Jena
  • Friedrich-Alexander University Erlangen-Nürnberg
  • Johannes Gutenberg University Mainz
  • University Osnabruck
  • Ruhr University Bochum
  • Heidelberg University 
  • University of Bonn
  • German Social Accident Insurance
  • Medical Faculty Carl Gustav Carus
  • TUD Dresden University of Technology

Abstract

Objective: The aimof this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC). Methods: We undertook a population-based multicenter case-control study. Patients with first incident BCC (n=836) were propensity score matched by age and sex to controls without skin cancer (n=836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models. Results: Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22) occupational UV-exposure. Nonoccupational UVexposure was not independently associated with BCC. Conclusion: Skin cancer prevention strategies should be expanded to the occupational setting.

Details

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalJournal of occupational and environmental medicine
Volume60
Issue number1
Publication statusPublished - 1 Jan 2018
Peer-reviewedYes

External IDs

PubMed 29111985
ORCID /0000-0002-4411-3088/work/141543492

Keywords