This research presents an experimental and numerical study on the heat transfer of -Al2O3/water nanofluid flowing through the double pipe and shell and tube heat exchangers, under laminar flow conditions. Effects of important parameters such as hot and cold volume flow rates, nanofluid temperature, and nanoparticles concentration on the heat transfer characteristics are investigated. The results indicated that the heat transfer performance of both double pipe and shell and tube heat exchangers increases with increasing the hot and cold volume flow rates, as well as the particle concentrations and nanofluid inlet temperature. Compared with pure water, the results indicated that the heat transfer coefficients of nanofluid in the double pipe and shell and tube heat exchangers are higher than those of water by 13.2% and 21.3%, respectively. Also, the heat transfer performance of nanofluid in a shell and tube heat exchanger is 26.2% higher than the double pipe heat exchanger. A computational fluid dynamics (CFD) technique was used for heat transfer simulation in the previously mentioned heat exchangers. Computed overall heat transfer coefficients of the nanofluids are in good agreement with the experimental data.