Novel methods in adrenal research: a metabolomics approach
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Metabolic alterations have implications in a spectrum of tissue functions and disease. Aided by novel molecular biological and computational tools, our understanding of physiological and pathological processes underpinning endocrine and endocrine-related disease has significantly expanded over the last decade. Herein, we focus on novel metabolomics-related methodologies in adrenal research: in situ metabolomics by mass spectrometry imaging, steroid metabolomics by gas and liquid chromatography–mass spectrometry, energy pathway metabologenomics by liquid chromatography–mass spectrometry-based metabolomics of Krebs cycle intermediates, and cellular reprogramming to generate functional steroidogenic cells and hence to modulate the steroid metabolome. All four techniques to assess and/or modulate the metabolome in biological systems provide tremendous opportunities to manage neoplastic and non-neoplastic disease of the adrenal glands in the era of precision medicine. In this context, we discuss emerging clinical applications and/or promising metabolic-driven research towards diagnostic, prognostic, predictive and therapeutic biomarkers in tumours arising from the adrenal gland and extra-adrenal paraganglia as well as modern approaches to delineate and reprogram adrenal metabolism.
Details
Original language | English |
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Pages (from-to) | 201-216 |
Number of pages | 16 |
Journal | Histochemistry and cell biology |
Volume | 151 |
Issue number | 3 |
Publication status | Published - 5 Mar 2019 |
Peer-reviewed | Yes |
External IDs
PubMed | 30725173 |
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ORCID | /0000-0002-3549-2477/work/142244897 |
Keywords
ASJC Scopus subject areas
Keywords
- Adrenal glands, Cellular reprogramming, In situ metabolomics, Metabologenomics, Steroid metabolomics