Novel aspects in the regulation of the leukocyte adhesion cascade

Research output: Contribution to journalResearch articleContributedpeer-review


  • Emmanouil Chavakis - , University Hospital Frankfurt (Author)
  • Young Choi Eun - , National Institutes of Health (NIH) (Author)
  • Triantafyllos Chavakis - , National Institutes of Health (NIH) (Author)


Leukocyte recruitment plays a major role in the immune response to infectious pathogens and during inflammatory and autoimmune disorders. The process of leukocyte extravasation from the blood into the inflamed tissue requires a complex cascade of adhesive events between the leukocytes and the endothelium including leukocyte rolling, adhesion and transendothelial migration. Leukocyte-endothelial interactions are mediated by tightly regulated binding interactions between adhesion receptors on both cells. In this regard, leukocyte adhesion onto the endothelium is governed by leukocyte integrins and their endothelial counter-receptors of the immunoglobulin superfamily. The present review will focus on novel aspects with respect to the modulation of the leukocyte adhesion cascade.


Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalThrombosis and Haemostasis
Issue number2
Publication statusPublished - Aug 2009
Externally publishedYes

External IDs

Scopus 70350450886
PubMed 19652868


ASJC Scopus subject areas


  • Adhesion receptors, Cell-cell interactions, Endothelial cells, Inflammation, Integrins