Novel aspects in the regulation of the leukocyte adhesion cascade
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Leukocyte recruitment plays a major role in the immune response to infectious pathogens and during inflammatory and autoimmune disorders. The process of leukocyte extravasation from the blood into the inflamed tissue requires a complex cascade of adhesive events between the leukocytes and the endothelium including leukocyte rolling, adhesion and transendothelial migration. Leukocyte-endothelial interactions are mediated by tightly regulated binding interactions between adhesion receptors on both cells. In this regard, leukocyte adhesion onto the endothelium is governed by leukocyte integrins and their endothelial counter-receptors of the immunoglobulin superfamily. The present review will focus on novel aspects with respect to the modulation of the leukocyte adhesion cascade.
Details
Original language | English |
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Pages (from-to) | 191-197 |
Number of pages | 7 |
Journal | Thrombosis and Haemostasis |
Volume | 102 |
Issue number | 2 |
Publication status | Published - Aug 2009 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
Scopus | 70350450886 |
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PubMed | 19652868 |
Keywords
ASJC Scopus subject areas
Keywords
- Adhesion receptors, Cell-cell interactions, Endothelial cells, Inflammation, Integrins