No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Robert A. Scott - , Cambridge University Hospitals NHS Foundation Trust (Author)
  • Audrey Y. Chu - , Harvard University, Johns Hopkins University (Author)
  • Niels Grarup - , Novo Nordisk Foundation Center for Basic Metabolic Research, Novo Nordisk Foundation (Author)
  • Alisa K. Manning - , Boston University (Author)
  • Marie France Hivert - , Université de Sherbrooke (Author)
  • Dmitry Shungin - , Lund University, Umeå University (Author)
  • Anke Tönjes - , Leipzig University (Author)
  • Ajay Yesupriya - , Centers for Disease Control and Prevention (Author)
  • Daniel Barnes - , Cambridge University Hospitals NHS Foundation Trust (Author)
  • Nabila Bouatia-Naji - , French National Centre for Scientific Research (CNRS), Université de Lille (Author)
  • Nicole L. Glazer - , Boston University (Author)
  • Anne U. Jackson - , University of Michigan, Ann Arbor (Author)
  • Zoltán Kutalik - , University of Lausanne, Swiss Institute of Bioinformatics (Author)
  • Vasiliki Lagou - , University of Oxford (Author)
  • Diana Marek - , University of Lausanne, Swiss Institute of Bioinformatics (Author)
  • Laura J. Rasmussen-Torvik - , Northwestern University (Author)
  • Heather M. Stringham - , University of Michigan, Ann Arbor (Author)
  • Toshiko Tanaka - , National Institutes of Health (NIH) (Author)
  • Mette Aadahl - , University of Copenhagen (Author)
  • Dan E. Arking - , Johns Hopkins University (Author)
  • Sven Bergmann - , University of Lausanne, Swiss Institute of Bioinformatics (Author)
  • Eric Boerwinkle - , University of Texas Health Science Center at Houston (Author)
  • Lori L. Bonnycastle - , National Institutes of Health (NIH) (Author)
  • Stefan R. Bornstein - , Department of Internal Medicine III (Author)
  • Eric Brunner - , University College London (Author)
  • Suzannah J. Bumpstead - , Wellcome Sanger Institute (Author)
  • Soren Brage - , Cambridge University Hospitals NHS Foundation Trust (Author)
  • Olga D. Carlson - , National Institutes of Health (NIH) (Author)
  • Han Chen - , Boston University (Author)
  • Yii Der Ida Chen - , Cedars-Sinai Medical Center (Author)
  • Peter S. Chines - , National Institutes of Health (NIH) (Author)
  • Francis S. Collins - , National Institutes of Health (NIH) (Author)
  • David J. Couper - , University of North Carolina at Chapel Hill (Author)
  • Elaine M. Dennison - , University of Southampton (Author)
  • Nicole F. Dowling - , Centers for Disease Control and Prevention (Author)
  • Josephine S. Egan - , National Institutes of Health (NIH) (Author)
  • Ulf Ekelund - , Cambridge University Hospitals NHS Foundation Trust (Author)
  • Michael R. Erdos - , National Institutes of Health (NIH) (Author)
  • Nita G. Forouhi - , Cambridge University Hospitals NHS Foundation Trust (Author)
  • Caroline S. Fox - , National Institutes of Health (NIH), Harvard University (Author)
  • Mark O. Goodarzi - , Cedars-Sinai Medical Center (Author)
  • Jürgen Grässler - , Department of Internal Medicine III (Author)
  • Stefan Gustafsson - , Karolinska Institutet (Author)
  • Göran Hallmans - , Umeå University (Author)
  • Torben Hansen - , Novo Nordisk Foundation Center for Basic Metabolic Research, Novo Nordisk Foundation, University of Southern Denmark (Author)
  • Aroon Hingorani - , University College London (Author)
  • John W. Holloway - , University of Southampton (Author)
  • Frank B. Hu - , Harvard University (Author)
  • Bo Isomaa - , Folkhalsan, City of Helsinki (Author)
  • Karen A. Jameson - , University of Southampton (Author)
  • Ingegerd Johansson - , Umeå University (Author)
  • Anna Jonsson - , Lund University (Author)
  • Torben Jørgensen - , University of Copenhagen (Author)
  • Mika Kivimaki - , University College London (Author)
  • Peter Kovacs - , Leipzig University (Author)
  • Meena Kumari - , University College London (Author)
  • Johanna Kuusisto - , University of Eastern Finland (Author)
  • Markku Laakso - , University of Eastern Finland (Author)
  • Cécile Lecoeur - , French National Centre for Scientific Research (CNRS), Université de Lille (Author)
  • Claire Lévy-Marchal - , Université de Lille, Assistance publique – Hôpitaux de Paris (Author)
  • Guo Li - , University of Washington (Author)
  • Ruth J.F. Loos - , Cambridge University Hospitals NHS Foundation Trust (Author)
  • Valeri Lyssenko - , Lund University (Author)
  • Michael Marmot - , University College London (Author)
  • Pedro Marques-Vidal - , University of Lausanne (Author)
  • Mario A. Morken - , National Institutes of Health (NIH) (Author)
  • Gabriele Müller - , Institute for Medical Informatics and Biometry (Author)
  • Kari E. North - , University of North Carolina at Chapel Hill (Author)
  • James S. Pankow - , University of Minnesota System (Author)
  • Felicity Payne - , Wellcome Sanger Institute (Author)
  • Inga Prokopenko - , University of Oxford (Author)
  • Bruce M. Psaty - , University of Washington, Group Health Cooperative (Author)
  • Frida Renström - , Lund University, Harvard University (Author)
  • Ken Rice - , University of Washington (Author)
  • Jerome I. Rotter - , Cedars-Sinai Medical Center (Author)
  • Denis Rybin - , Boston University (Author)
  • Camilla H. Sandholt - , Novo Nordisk Foundation Center for Basic Metabolic Research, Novo Nordisk Foundation (Author)
  • Avan A. Sayer - , University of Southampton (Author)
  • Peter Shrader - , Harvard University, Massachusetts General Hospital (Author)
  • Peter E.H. Schwarz - , Department of Internal Medicine III (Author)
  • David S. Siscovick - , University of Washington (Author)
  • Alena Stančáková - , University of Eastern Finland (Author)
  • Michael Stumvoll - , Leipzig University (Author)
  • Tanya M. Teslovich - , University of Michigan, Ann Arbor (Author)
  • Gérard Waeber - , University of Lausanne (Author)
  • Gordon H. Williams - , Harvard University (Author)
  • Daniel R. Witte - , Novo Nordisk Foundation (Author)
  • Andrew R. Wood - , University of Plymouth (Author)
  • Weijia Xie - , University of Plymouth (Author)
  • Michael Boehnke - , University of Michigan, Ann Arbor (Author)
  • Cyrus Cooper - , University of Southampton, University of Oxford (Author)
  • Luigi Ferrucci - , National Institutes of Health (NIH) (Author)
  • Philippe Froguel - , French National Centre for Scientific Research (CNRS), Université de Lille, Imperial College London (Author)
  • Leif Groop - , Lund University (Author)
  • W. H.Linda Kao - , Johns Hopkins University (Author)
  • Peter Vollenweider - , University of Lausanne (Author)
  • Mark Walker - , Newcastle University (Author)
  • Richard M. Watanabe - , Keck School of Medicine at University of Southern California (Author)
  • Oluf Pedersen - , Novo Nordisk Foundation Center for Basic Metabolic Research, Novo Nordisk Foundation, University of Copenhagen, Aarhus University (Author)
  • James B. Meigs - , Harvard University, Massachusetts General Hospital (Author)
  • Erik Ingelsson - , Karolinska Institutet (Author)
  • Inês Barroso - , Wellcome Sanger Institute, University of Cambridge (Author)
  • Jose C. Florez - , Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) (Author)
  • Paul W. Franks - , Lund University, Umeå University, Harvard University (Author)
  • Josée Dupuis - , Boston University, National Institutes of Health (NIH) (Author)
  • Nicholas J. Wareham - , Cambridge University Hospitals NHS Foundation Trust (Author)
  • Claudia Langenberg - , Cambridge University Hospitals NHS Foundation Trust (Author)

Abstract

Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SNP X physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10 -6). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10 -7), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.

Details

Original languageEnglish
Pages (from-to)1291-1296
Number of pages6
JournalDiabetes
Volume61
Issue number5
Publication statusPublished - May 2012
Peer-reviewedYes

External IDs

PubMed 22415877

Keywords