The study aimed to investigate possible differences in lateralized olfactory processing in left- and right-handed subjects using a functional MRI paradigm. Twenty-four (14 female, 10 male) right-handers and 24 (14 female, 10 male) left-handers participated; their mean age was 24.0 years, all were in excellent health with no indication of any major nasal or other health problems. The rose-like odor phenyl ethyl alcohol and the smell of rotten eggs (H ₂S) were used for relatively specific olfactory activation in a block design using a 1.5-T MR scanner. Results indicated no major differences in lateralized olfactory activation between left- and right-handers. This suggests that in simple olfactory tasks, handedness does not seem to play a substantial role in the processing of olfactory information.