Nicotine administration in healthy non-smokers reduces appetite but does not alter plasma ghrelin
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Objective We studied whether suppressed secretion of the orexigenic peptide ghrelin might be involved in the anorexigenic effects of nicotine. Methods Fifty healthy non-smokers chewed gums containing 2 mg nicotine, or no nicotine in a double-blind randomised crossover design in two independent studies. Results Plasma nonacylated ghrelin was not significantly affected by nicotine after 30 and 60 min. Increased blood pressure and decreased appetite ratings confirmed a biological nicotine effect. Conclusions These results do not support a key role of peripheral ghrelin secretion in weight changes related to smoking or smoking cessation, but do not rule out that central nervous system ghrelin is involved.
Details
Original language | English |
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Pages (from-to) | 384-387 |
Number of pages | 4 |
Journal | Human Psychopharmacology |
Volume | 29 |
Issue number | 4 |
Publication status | Published - Jul 2014 |
Peer-reviewed | Yes |
External IDs
PubMed | 24710917 |
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ORCID | /0000-0001-5398-5569/work/150329556 |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- appetite, blood pressure, ghrelin, nicotine