Nicotine administration in healthy non-smokers reduces appetite but does not alter plasma ghrelin

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Maximilian Pilhatsch - , Department of Psychiatry and Psychotherapy, TUD Dresden University of Technology (Author)
  • Hannah Scheuing - , TUD Dresden University of Technology (Author)
  • Nils Kroemer - , TUD Dresden University of Technology (Author)
  • Andrea Kobiella - , TUD Dresden University of Technology (Author)
  • Martin Bidlingmaier - , Ludwig Maximilian University of Munich (Author)
  • Gisbert Farger - , University of Tübingen (Author)
  • Michael N. Smolka - , Department of Psychiatry and Psychotherapy, TUD Dresden University of Technology (Author)
  • Ulrich S. Zimmermann - , TUD Dresden University of Technology (Author)

Abstract

Objective We studied whether suppressed secretion of the orexigenic peptide ghrelin might be involved in the anorexigenic effects of nicotine. Methods Fifty healthy non-smokers chewed gums containing 2 mg nicotine, or no nicotine in a double-blind randomised crossover design in two independent studies. Results Plasma nonacylated ghrelin was not significantly affected by nicotine after 30 and 60 min. Increased blood pressure and decreased appetite ratings confirmed a biological nicotine effect. Conclusions These results do not support a key role of peripheral ghrelin secretion in weight changes related to smoking or smoking cessation, but do not rule out that central nervous system ghrelin is involved.

Details

Original languageEnglish
Pages (from-to)384-387
Number of pages4
JournalHuman Psychopharmacology
Volume29
Issue number4
Publication statusPublished - Jul 2014
Peer-reviewedYes

External IDs

PubMed 24710917
ORCID /0000-0001-5398-5569/work/150329556

Keywords

Sustainable Development Goals

Keywords

  • appetite, blood pressure, ghrelin, nicotine