New frontiers in atomic force microscopy: Analyzing interactions from single-molecules to cells
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Originally invented for imaging surfaces, atomic force microscopy (AFM) has evolved into a multifunctional molecular toolkit, enabling us to investigate the interactions of biological systems over scales ranging from single-molecules to whole cells. Specific highlights include the nanoscale imaging of the chemical properties of individual cells, the detection and functional analysis of cell surface receptors using single-molecule force spectroscopy and the quantitative measurement of cellular interactions using single-cell force spectroscopy. These advanced force spectroscopy modalities offer new opportunities for understanding the molecular bases of cell adhesion processes, which is a fundamental challenge in current life science and biotech research.
Details
Original language | English |
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Pages (from-to) | 4-13 |
Number of pages | 10 |
Journal | Current opinion in biotechnology |
Volume | 20 |
Issue number | 1 |
Publication status | Published - Feb 2009 |
Peer-reviewed | Yes |
External IDs
Scopus | 65449173267 |
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Keywords
Keywords
- Cell Adhesion/physiology, Microscopy, Atomic Force/methods, Models, Theoretical, Receptors, Cell Surface/metabolism