Nerve fibers in the tumor microenvironment are co-localized with lymphoid aggregates in pancreatic cancer
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
B cells and tertiary lymphoid structures (TLS) are reported to be important in survival in cancer. Pancreatic Cancer (PDAC) is one of the most lethal cancer types, and currently, it is the seventh leading cause of cancer-related death worldwide. A better understanding of tumor biology is pivotal to improve clinical outcome. The desmoplastic stroma is a complex system in which cross-talk takes place between cancer-associated fibroblasts, immune cells and cancer cells. Indirect and direct cellular interactions within the tumor microenvironment (TME) drive key processes such as tumor progression, metastasis formation and treatment resistance. In order to understand the aggressiveness of PDAC and its resistance to therapeutics, the TME needs to be further unraveled. There are some limited data about the influence of nerve fibers on cancer progression. Here we show that small nerve fibers are located at lymphoid aggregates in PDAC. This unravels future pathways and has potential to improve clinical outcome by a rational development of new therapeutic strategies.
Details
Original language | English |
---|---|
Article number | 490 |
Pages (from-to) | 1-12 |
Number of pages | 12 |
Journal | Journal of clinical medicine |
Volume | 10 |
Issue number | 3 |
Publication status | Published - 1 Feb 2021 |
Peer-reviewed | Yes |
Externally published | Yes |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Machine learning, Nerve fiber density, Pancreatic cancer, Spatial arrangements, Tertiary lymphoid structures, Tumor microenvironment