Neointimal hyperplasia in allogeneic and autologous venous grafts is not different in nature

Research output: Contribution to journalResearch articleContributedpeer-review


  • Albert Busch - , University Hospital of Würzburg (Author)
  • Elena Hartmann - (Author)
  • Nicole Wagner - (Author)
  • Süleyman Ergün - (Author)
  • Ralph Kickuth - (Author)
  • Richard Kellersmann - (Author)
  • Udo Lorenz - (Author)


Neointimal hyperplasia, transplant rejection and thus immunogenicity of allografts are possible reasons for poorer patency rates in cryopreserved venous allografts for peripheral bypass surgery in comparison with autologous venous grafts. To expand the limited knowledge from human allografts, we histologically investigated allogeneic and autologous venous grafts in arterial location. Specimens of allogeneic and autologous venous graft stenosis, harvested 6 months after bypass implantation, were immunohistochemically characterized. Examination of the lesions showed a uniform morphological pattern. A continuous endothelial layer, tissue fibrosis and a thickened neointima with monocytes and dedifferentiated vascular smooth muscle cells were seen in both conduits with very low cell turnover and the absence of acute and chronic inflammation. Neoangiogenesis with CD34-positive endothelium was abundant in the vessel media. The morphological patterns of allogeneic and autologous neointima formation are similar. Consequently, neointimal hyperplasia in venous grafts may reflect a uniform physiological host response of non-immunological factors with the reasons for poorer clinical outcome of cryopreserved allografts yet to be elucidated.


Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalHistochemistry and cell biology
Issue number1
Publication statusPublished - Jul 2015
Externally publishedYes

External IDs

Scopus 84931566973



  • Allografts, Autografts, Cryopreservation, Endothelium, Vascular/pathology, Humans, Hyperplasia, Muscle, Smooth, Vascular/pathology, Neointima/immunology, Neovascularization, Pathologic, Saphenous Vein/transplantation