Near-critical fluctuations and cytoskeleton-assisted phase separation lead to subdiffusion in cell membranes
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Contributors
Abstract
We address the relationship between membrane microheterogeneity and anomalous subdiffusion in cell membranes by carrying out Monte Carlo simulations of two-component lipid membranes. We find that near-critical fluctuations in the membrane lead to transient subdiffusion, while membrane-cytoskeleton interaction strongly affects phase separation, enhances subdiffusion, and eventually leads to hop diffusion of lipids. Thus, we present a minimum realistic model for membrane rafts showing the features of both microscopic phase separation and subdiffusion.
Details
Original language | English |
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Pages (from-to) | 80-89 |
Number of pages | 10 |
Journal | Biophysical journal |
Volume | 100 |
Issue number | 1 |
Publication status | Published - 5 Jan 2011 |
Peer-reviewed | Yes |