Near infrared Raman spectroscopy to study the composition of human brain tissue and tumors

Research output: Contribution to book/Conference proceedings/Anthology/Report › Conference contribution › Contributed › peer-review

Contributors

  • Christoph Krafft - , TUD Dresden University of Technology (Author)
  • S. Miljanic - , TUD Dresden University of Technology (Author)
  • Stephan B. Sobottka - , Department of Neurosurgery, TUD Dresden University of Technology (Author)
  • Gabriele Schackert - , TUD Dresden University of Technology (Author)
  • Reiner Salzer - , TUD Dresden University of Technology (Author)

Abstract

The composition of human brain tissue and brain tumors were studied by near infrared Raman spectroscopy with 785 nm excitation. The amounts of lipids, cholesterol, protein and water in fresh specimens were determined from Raman spectra by a combination of pure component spectra. Normal brain tissue was found to contain higher levels of lipids and cholesterol, brain tumors such as glioma and meningeoma displayed less lipids and cholesterol, but more proteins, in particular more hemoglobin-like molecules. These results demonstrate the applicability of Raman spectroscopy for real-time, in vivo, intraoperative diagnosis.

Details

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics 2003
PublisherOptica Publishing Group (formerly OSA)
Chapter5141_230
Pages230-236
Number of pages7
ISBN (electronic)0819450111
Publication statusPublished - 2003
Peer-reviewedYes

Publication series

Series Proceedings of SPIE - The International Society for Optical Engineering
Volume5141
ISSN0277-786X

Conference

TitleEuropean Conference on Biomedical Optics 2003
Abbreviated titleECBO 2003
Duration22 - 25 June 2003
Website
Degree of recognitionInternational event
CityMünchen
CountryGermany

External IDs

Scopus 85136114294

Keywords

ASJC Scopus subject areas

Keywords

  • Brain tissue, Brain tumors, Raman spectroscopy, Tumor diagnostics