NaviCenta - The disease map for placental research

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

The placenta remains the key organ to pregnancy complications, such as preeclampsia, contrarily the pathophysiology underlying the placental dysfunctions remains elusive. Here, we present our Disease Map "NaviCenta", which is an online resource based on the interactions between tissues, cellular compartments, and molecules that mediate disease-related processes in the placenta. We built cellular and molecular interaction networks based upon manual curation and annotation of publicly available information in the scientific literature, pathways resources, and Omics data. NaviCenta (Navigate the plaCenta) serves as an open access, spatio-temporal, multi-scale knowledge base, and analytical tool for enhanced interpretation and hypothesis testing on various placental disease phenotypes.

Details

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalPlacenta
Volume143 (2023)
Early online date19 Sept 2023
Publication statusPublished - Nov 2023
Peer-reviewedYes

External IDs

ORCID /0000-0002-1887-4772/work/143962318
Scopus 85172689156

Keywords

Keywords

  • Pregnancy, Pregnancy Complications/metabolism, Pre-Eclampsia/metabolism, Humans, Placenta/metabolism, Female, Placenta Diseases/metabolism

Library keywords