For the detailed analysis of tire-pavement interaction, its structural components (tire, pavement, tire-pavement interface) have been represented in finite-elementdiscretized form within a thermo-mechanical simulation approach. The tire-pavement model captures short-term phenomena (rolling tire, day-night temperature change) as well as long-term phenomena (annual temperature change, change of traffic intensity). Several submodels (tire, multiscale friction law, pavement structure) have been developed considering different length and time scales in combination with an arbitrary Lagrangian Eulerian (ALE) formulation for tire and pavement (steady state rolling condition). In this contribution, a mesostructure inspired material model for asphalt is proposed to realistically capture the material behavior within the described simulation approach. The material model consists of a short- and a long-term part connected in series and represents the material’s short- and long-term response to repetitive loading.