Monocytes compensate Kupffer cell loss during bacterial infection

Research output: Contribution to journal › Research article › Invited

Contributors

  • Kaaweh Molawi - , Centre d'Immunologie de Marseille-Luminy (CIML) (Author)
  • Michael H Sieweke - , Aix-Marseille Université, INSERM - Institut national de la santé et de la recherche médicale, French National Centre for Scientific Research (CNRS), Max Delbrück Center for Molecular Medicine (MDC) (Author)

Abstract

Liver Kupffer cells (KCs) are self-maintained tissue-resident macrophages. In this issue of Immunity, Blériot et al. demonstrate that bacterial infection leads to KC necroptosis and quantitative replacement by monocyte-derived macrophages that contribute to antibacterial immunity and restoration of tissue integrity.

Details

Original languageEnglish
Pages (from-to)10-2
Number of pages3
JournalImmunity
Volume42
Issue number1
Publication statusPublished - 20 Jan 2015
Peer-reviewedNo
Externally publishedYes

External IDs

Scopus 84921293907

Keywords

Keywords

  • Animals, Kupffer Cells/physiology, Listeria monocytogenes/immunology, Listeriosis/immunology, Liver/pathology, Monocytes/immunology