Molecular tools in the detection of micrometastatic cancer cells--technical aspects and clinical relevance.

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • M. von Knebel Doeberitz - , Heidelberg University  (Author)
  • J. Weitz - , Heidelberg University  (Author)
  • M. Koch - , Heidelberg University  (Author)
  • J. Lacroix - , Heidelberg University  (Author)
  • A. Schrödel - , Heidelberg University  (Author)
  • C. Herfarth - , Heidelberg University  (Author)

Abstract

The frequent failure to reduce the mortality due to epithelial cancers by common medical intervention results primarily from early dissemination of cancer cells, which is missed by conventional diagnostic procedures used for tumor staging. Individual carcinoma cells present in regional lymph nodes, blood or distant organs (e.g., bone marrow) can be detected by sensitive immunologic or molecular methods. Here, we review recently developed molecular assays for the detection of individual micrometastatic cancer cells and their clinical application in patients with epithelial tumors.

Details

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
Volume158
Publication statusPublished - 2001
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 11092045

Keywords

Sustainable Development Goals

ASJC Scopus subject areas