Resolving the severe issues such as electric field distortion, dendritic zinc growth, and uneven zinc deposition under high depths of discharge (DOD) has become a significant hurdle of the aqueous zinc-ion batteries (ZIBs). To address these challenges, an interfacial regulation strategy is proposed based on the molecular damping effect, in which a trace amount of weakly adsorbing additive is employed to stabilize the Zn anode interface by mitigating energy shocks and ionic disturbances induced by electric field fluctuations. Trace perfluorinated PSVE (erfluoro-3,6-dioxa-4-methyloct-7-enesulphonyl fluoride) is introduced to the traditional ZnSO₄ electrolyte to optimize Zn deposition behavior on the zinc anode. Thus, the Zn//Zn symmetric batteries exhibit a prolonged cycling lifespan of over 200 h, even when operated at a high DOD of 85.5%. Additionally, the NVO (Na₂V₆O₁₆) cathodes coupled with Zn anodes and modified electrolyte present a more stable capacity retention, maintaining a capacity of 141.98 mAh g⁻¹ after 1000 cycles. Similarly, the full batteries assembled with the same electrodes in a ZnSO₄ electrolyte retain only 51.49 mAh g⁻¹ capacity after the same conditions. This work highlights the potential of the molecular damping effect as a promising solution for improving high DOD performance in ZIBs.