Minimal Model of Cellular Symmetry Breaking

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

The cell cortex, a thin film of active material assembled below the cell membrane, plays a key role in cellular symmetry-breaking processes such as cell polarity establishment and cell division. Here, we present a minimal model of the self-organization of the cell cortex that is based on a hydrodynamic theory of curved active surfaces. Active stresses on this surface are regulated by a diffusing molecular species. We show that coupling of the active surface to a passive bulk fluid enables spontaneous polarization and the formation of a contractile ring on the surface via mechanochemical instabilities. We discuss the role of external fields in guiding such pattern formation. Our work reveals that key features of cellular symmetry breaking and cell division can emerge in a minimal model via general dynamic instabilities.

Details

Original languageEnglish
Article number188101
JournalPhysical review letters
Volume123
Issue number18
Publication statusPublished - 28 Oct 2019
Peer-reviewedYes

External IDs

PubMed 31763902
ORCID /0000-0003-4414-4340/work/142252167

Keywords