Mild, Selective Ru-Catalyzed Deuteration Using D2O as a Deuterium Source

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Pascal Eisele - , University of Stuttgart (Author)
  • Franziska Ullwer - , University of Stuttgart (Author)
  • Sven Scholz - , University of Stuttgart (Author)
  • Bernd Johannes Plietker - , University of Stuttgart (Author)

Abstract

A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl2(PPh3)3] and D2O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru-complexes under the given specific conditions.

Details

Original languageEnglish
Pages (from-to)16550-16554
Number of pages5
JournalChemistry - A European Journal
Volume25
Issue number72
Publication statusPublished - 20 Dec 2019
Peer-reviewedYes
Externally publishedYes

External IDs

ORCID /0000-0001-8423-6173/work/142660201

Keywords

ASJC Scopus subject areas

Keywords

  • catalysis, C−H activation, deuterium, isotopes, ruthenium

Library keywords