Microrobot's Performance in Cell-Lining Surfaces and Ex-vivo Tissue

Research output: Contribution to book/Conference proceedings/Anthology/ReportConference contributionContributedpeer-review

Contributors

  • C. Ribeiro - , Leibniz Institute for Solid State and Materials Research Dresden (Author)
  • R. Nauber - , Leibniz Institute for Solid State and Materials Research Dresden (Author)
  • A. Aziz - , Leibniz Institute for Solid State and Materials Research Dresden (Author)
  • D.C. Robles - , Micro- and Nano-Biosystems (Research Group), Leibniz Institute for Solid State and Materials Research Dresden (Author)
  • F. Hebenstreit - , Leibniz Institute for Solid State and Materials Research Dresden (Author)
  • M. Medina-Sánchez - , Micro- and Nano-Biosystems (Research Group), Leibniz Institute for Solid State and Materials Research Dresden, Ikerbasque Basque Foundation for Science (Author)

Abstract

Medical microrobots (MRs) have emerged as promising tools for various biomedical applications, spanning therapeutics, diagnostics, and surgical interventions.Of particular interest is their potential in the female reproductive tract, where the intricate nature of the organs presents unique challenges and opportunities.However, our understanding of how these microrobots perform in this complex environment remains limited.This study, aims to assess the motion capabilities of various MRs designs, including spiral embryo carriers, soft-capsule alginate beads, and therapeutic Janus particles, across diverse environmental conditions.Specifically, we focused on evaluating their performance on a cell monolayer that simulates the lining of the reproductive tract.Our findings reveal that the motion of these microrobots above cell-coated channels does not compromise cell viability.Furthermore, we demonstrate the successful propulsion of Janus micromotors coated with cumulus cells as a camouflage to improve their performance in ex vivo bovine oviduct tissue.This study enhances our understanding of MRs dynamics in the female reproductive tract and lays the basis for their future integration into targeted therapeutic and diagnostic strategies in gynecological medicine.

Details

Original languageEnglish
Title of host publicationProceedings of MARSS 2024 - 7th International Conference on Manipulation, Automation, and Robotics at Small Scales
EditorsSinan Haliyo, Mokrane Boudaoud, Massimo Mastrangeli, Pierre Lambert, Sergej Fatikow
Pages1-6
ISBN (electronic)979-8-3503-7680-7
Publication statusPublished - 2024
Peer-reviewedYes

External IDs

Scopus 85202354500