MicroRNA and Diabetic Bone Disease

Research output: Contribution to journalReview articleContributed

Contributors

Abstract

PURPOSE OF REVIEW: The incidence of diabetes is increasing worldwide. Diabetes mellitus is characterized by hyperglycemia, which in the long-term damages the function of many organs including the eyes, the vasculature, the nervous system, and the kidneys, thereby imposing an important cause of morbidity for affected individuals. More recently, increased bone fragility was also noted in patients with diabetes. While patients with type 1 diabetes mellitus (T1DM) have low bone mass and a 6-fold risk for hip fractures, patients with type 2 diabetes mellitus (T2DM) have an increased bone mass, yet still display a 2-fold elevated risk for hip fractures. Although the underlying mechanisms are just beginning to be unraveled, it is clear that diagnostic tools are lacking to identify patients at risk for fracture, especially in the case of T2DM, in which classical tools to diagnose osteoporosis such as dual X-ray absorptiometry have limitations. Thus, new biomarkers are urgently needed to help identify patients with diabetes who are at risk to fracture.

RECENT FINDINGS: Previously, microRNAs have received great attention not only for being involved in the pathogenesis of various chronic diseases, including osteoporosis, but also for their value as biomarkers. Here, we summarize the current knowledge on microRNAs and their role in diabetic bone disease and highlight recent studies on miRNAs as biomarkers to predict bone fragility in T1DM and T2DM. Finally, we discuss future directions and challenges for their use as prognostic markers.

Details

Original languageEnglish
Pages (from-to)194-201
Number of pages8
JournalCurrent osteoporosis reports
Volume20
Issue number3
Publication statusPublished - Jun 2022
Peer-reviewedNo

External IDs

PubMedCentral PMC9209361
Scopus 85131604281
unpaywall 10.1007/s11914-022-00731-0
Mendeley d63c04b0-75c7-32b3-8c48-993902d0f8ac
ORCID /0000-0002-8691-8423/work/142236005

Keywords

Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards

Subject groups, research areas, subject areas according to Destatis

Sustainable Development Goals

Keywords

  • Biomarkers, Bone Density, Bone Diseases/complications, Diabetes Mellitus, Type 1/complications, Diabetes Mellitus, Type 2/epidemiology, Hip Fractures/epidemiology, Humans, MicroRNAs, Osteoporosis/epidemiology, Bone fragility, Type 2 diabetes mellitus, MicroRNA, Diabetic bone disease, Type 1 diabetes mellitus

Library keywords