Metabolic implications of pancreatic fat accumulation

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Robert Wagner - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Sabine S. Eckstein - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Hajime Yamazaki - , Kyoto University (Author)
  • Felicia Gerst - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Jürgen Machann - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Benjamin Assad Jaghutriz - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Annette Schürmann - , German Center for Diabetes Research (DZD e.V.), German Institute of Human Nutrition Potsdam-Rehbruecke, University of Potsdam (Author)
  • Michele Solimena - , Molecular Diabetology, German Center for Diabetes Research (DZD e.V.), University Hospital Carl Gustav Carus Dresden, Medical Faculty Carl Gustav Carus (Author)
  • Stephan Singer - , University of Tübingen (Author)
  • Alfred Königsrainer - , University of Tübingen (Author)
  • Andreas L. Birkenfeld - , Department of Internal Medicine III, University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Hans Ulrich Häring - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Andreas Fritsche - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Susanne Ullrich - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)
  • Martin Heni - , University of Tübingen, German Center for Diabetes Research (DZD e.V.) (Author)

Abstract

Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received considerable attention, pancreatic fat has become an important area of research throughout the past 10 years. While a number of diagnostic approaches are available to quantify pancreatic fat, multi-echo Dixon MRI is currently the most developed method. Initial studies have shown associations between pancreatic fat and the metabolic syndrome, impaired glucose metabolism and type 2 diabetes mellitus. Pancreatic fat is linked to reduced insulin secretion, at least under specific circumstances such as prediabetes, low BMI and increased genetic risk of type 2 diabetes mellitus. This Review summarizes the possible causes and metabolic consequences of pancreatic fat accumulation. In addition, potential therapeutic approaches for addressing pancreatic fat accumulation are discussed.

Details

Original languageEnglish
Pages (from-to)43-54
Number of pages12
JournalNature Reviews Endocrinology
Volume2022
Issue number18(1)
Publication statusPublished - Jan 2022
Peer-reviewedYes

External IDs

PubMed 34671102

Keywords