Mechanisms of neutrophil transendothelial migration
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Neutrophil recruitment is an integral part of the immune response to infection as well as of inflammatory disorders. The process of neutrophil extravasation comprises a complex multistep cascade that is orchestrated by a tightly coordinated sequence of adhesive interactions with vessel wall endothelial cells. Adhesion receptors as well as signaling molecules in both neutrophils and endothelial cells regulate the recruitment of neutrophils into the site of inflammation or infection. The present review will focus on novel aspects with regards to the last step of neutrophil recruitment, namely the transmigration of neutrophils through endothelial cells.
Details
Original language | English |
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Pages (from-to) | 1596-1605 |
Number of pages | 10 |
Journal | Frontiers in Bioscience - Landmark |
Volume | 14 |
Issue number | 5 |
Publication status | Published - 1 Jan 2009 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
Scopus | 63849255311 |
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PubMed | 19273149 |
Keywords
ASJC Scopus subject areas
Keywords
- Adhesion, Endothelial cells, Inflammation, Junctions, Neutrophils, Review, Transmigration