Mechanisms of neutrophil transendothelial migration

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Eun Young Choi - , National Institutes of Health (NIH) (Author)
  • Sentot Santoso - , Justus Liebig University Giessen (Author)
  • Triantafyllos Chavakis - , National Institutes of Health (NIH) (Author)

Abstract

Neutrophil recruitment is an integral part of the immune response to infection as well as of inflammatory disorders. The process of neutrophil extravasation comprises a complex multistep cascade that is orchestrated by a tightly coordinated sequence of adhesive interactions with vessel wall endothelial cells. Adhesion receptors as well as signaling molecules in both neutrophils and endothelial cells regulate the recruitment of neutrophils into the site of inflammation or infection. The present review will focus on novel aspects with regards to the last step of neutrophil recruitment, namely the transmigration of neutrophils through endothelial cells.

Details

Original languageEnglish
Pages (from-to)1596-1605
Number of pages10
JournalFrontiers in Bioscience - Landmark
Volume14
Issue number5
Publication statusPublished - 1 Jan 2009
Peer-reviewedYes
Externally publishedYes

External IDs

Scopus 63849255311
PubMed 19273149

Keywords

Keywords

  • Adhesion, Endothelial cells, Inflammation, Junctions, Neutrophils, Review, Transmigration