Mathematical Modeling of Regenerative Processes
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
In many animals, regenerative processes can replace lost body parts. Organ and tissue regeneration consequently also hold great medical promise. The regulation of regenerative processes is achieved through concerted actions of multiple organizational levels of the organism, from diffusing molecules and cellular gene expression patterns up to tissue mechanics. Our intuition is usually not adapted well to this degree of complexity and the quantitative aspects of the regulation of regenerative processes remain poorly understood. One way out of this dilemma lies in the combination of experimentation and mathematical modeling within an iterative process of model development/refinement, model predictions for novel experimental conditions, quantitative experiments testing these predictions, and subsequent model refinement. This interdisciplinary approach has already provided key insights into smaller scale processes during embryonic development and a so-far limited number of more complex regeneration processes. This review discusses selected theoretical and interdisciplinary studies and is structured along the three phases of regeneration: (1) initiation of a regeneration response, (2) tissue patterning during regenerate growth, (3) arresting the regeneration response. Moreover, we highlight the opportunities provided by extensions of mathematical models from developmental processes toward the study of related regenerative processes.
Details
Original language | English |
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Pages (from-to) | 283-317 |
Number of pages | 35 |
Journal | Current topics in developmental biology |
Volume | 108 |
Publication status | Published - 2014 |
Peer-reviewed | Yes |
External IDs
Scopus | 84893584612 |
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ORCID | /0000-0003-0137-5106/work/142244230 |
Keywords
Keywords
- mathematical model, in silico model. simulation, computational biology, systems biology, regeneration