Background: Oases are azonal, highly productive, densely vegetated areas within drylands, often converted to agriculture, and characterized by significant biocultural diversity. Despite their importance, comprehensive information on the global distribution and biocultural diversity of oases has been lacking. Methods: To address this gap, a detailed bibliographic search and random forest modeling were combined to create a global map of oases, with a focus on Asia and North Africa (ANA). Results: In the ANA region, oases cover 1.5% of the dryland area and are populated by 150 million people, with an additional 268 million people living nearby and most likely being dependent on them. Globally, oases contain more than 8,200 vertebrate species, of which 13% are classified as threatened. However, less than 0.5% of their total area is currently under protection, making oases one of the least conserved ecosystems worldwide. These findings highlight the distinct biocultural, ecological, and geopolitical importance of oases, which are increasingly threatened by climate change and direct human impacts. Despite their significance, oases remain undervalued, emphasizing an urgent need for developing adaptative strategies to sustainably manage these pivotal ecosystems.