MAFB MUTANTS AND USES THEREOF
Research output: Intellectual Property › Patent application/Patent
Contributors
- Aix-Marseille Université
Abstract
The present invention relates to MafB mutants and uses thereof for research, screening and therapeutic purposes. In particular, the present invention relates to a MafB mutant polypeptide comprising the sequence as set forth in SEQ ID NO: 1 or 2 or a function conservative variant thereof wherein the glutaminic acid residue at position 269 has been deleted or substituted with a basic amino acid. The present invention also relates to a MafB mutant polypeptide comprising the sequence as set forth in SEQ ID NO: 1 or 2 or a function conservative variant thereof wherein the valine residue at position 277 has been deleted or substituted with a polar amino acid.
Details
The present invention relates to MafB mutants and uses thereof for research, screening and therapeutic purposes. In particular, the present invention relates to a MafB mutant polypeptide comprising the sequence as set forth in SEQ ID NO: 1 or 2 or a function conservative variant thereof wherein the glutaminic acid residue at position 269 has been deleted or substituted with a basic amino acid. The present invention also relates to a MafB mutant polypeptide comprising the sequence as set forth in SEQ ID NO: 1 or 2 or a function conservative variant thereof wherein the valine residue at position 277 has been deleted or substituted with a polar amino acid.
| Original language | English |
|---|---|
| IPC (International Patent Classification) | C07K 14/ 82 A I |
| Patent number | WO2015082525 |
| Filing date | 3 Dec 2014 |
| Country/Territory | Germany |
| Priority date | 3 Dec 2013 |
| Priority number | EP20130306661 |
| Publication status | Published - 11 Jun 2015 |
| Externally published | Yes |