Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Lymph nodes (LNs) are central in the generation of adaptive immune responses. Follicular helper CD4 T (Tfh) cells, a highly differentiated CD4 population, provide critical help for the development of antigen-specific B cell responses within the germinal center. Throughout the past decade, numerous studies have revealed the important role of Tfh cells in Human Immunodeficiency Virus (HIV) pathogenesis as well as in the development of neutralizing antibodies post-infection and post-vaccination. It has also been established that tumors influence various immune cell subsets not only in their proximity, but also in draining lymph nodes. The role of local or tumor associated lymph node Tfh cells in disease progression is emerging. Comparative studies of Tfh cells in chronic infections and cancer could therefore provide novel information with regards to their differentiation plasticity and to the mechanisms regulating their development.
Details
Original language | English |
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Article number | 2233 |
Journal | Frontiers in immunology |
Volume | 9 |
Publication status | Published - 27 Sept 2018 |
Peer-reviewed | Yes |
External IDs
PubMed | 30319664 |
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Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- cancer, follicles, HIV, lymph nodes, Tfh cells