Localized Morphea - A Rare but Significant Secondary Complication Following Breast Cancer Radiotherapy: Case Report and Review of the Literature on Radiation Reaction among Patients with Scleroderma/Morphea

Research output: Contribution to journalResearch articleContributedpeer-review


  • Thomas Herrmann - , Medical Faculty Carl Gustav Carus (Author)
  • Claudia Günther - , Department of Dermatology, University Hospital Carl Gustav Carus Dresden (Author)
  • Peter Csere - , Medical Faculty Carl Gustav Carus (Author)


Purpose and Approach To report a case of morphea (localized scleroderma) in a patient following breast cancer therapy and to summarize the current literature. Results and Conclusion The occurrence of morphea is an unexpected late effect (approximately 1 year after the end of radiation therapy) which occurs frequently in the irradiated breast in women with breast-conserving therapy. The pathogenesis is unclear. The main differential diagnoses are recurrence of carcinoma and a radiogenic subcutaneous fibrosis (in most cases, the final diagnosis can only be made by means of a biopsy). Diagnosis and therapy must be performed in cooperation between dermatologist and radiooncologist.


Original languageEnglish
Pages (from-to)603-607
Number of pages5
JournalStrahlentherapie und Onkologie
Issue number9
Publication statusPublished - Sept 2009

External IDs

PubMed 19756427
ORCID /0000-0002-4330-1861/work/151982006


Sustainable Development Goals


  • Breast cancer, Collagen vascular diseases, Localized scleroderma, Morphea