Local problems need global solutions: The metabolic needs of regenerating organisms

Research output: Contribution to journalReview articleContributedpeer-review



The vast majority of species that belong to the plant or animal kingdom evolved with two main strategies to counter tissue damage-scar formation and regeneration. Whereas scar formation provides a fast and cost-effective repair to exit life-threatening conditions, complete tissue regeneration is time-consuming and requires vast resources to reinstall functionality of affected organs or structures. Local environments in wound healing are widely studied and findings have provided important biomedical applications. Less well understood are organismic physiological parameters and signalling circuits essential to maintain effective tissue repair. Here, we review accumulated evidence that positions the interplay of local and systemic changes in metabolism as essential variables modulating the injury response. We particularly emphasise the role of lipids and lipid-like molecules as significant components long overlooked.


Original languageEnglish
Pages (from-to)652-664
Number of pages13
Journal Wound repair and regeneration : the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association
Issue number6
Early online date21 May 2022
Publication statusPublished - 5 Jun 2022

External IDs

PubMed 35596643
Scopus 85131558067
WOS 000806114400001


Research priority areas of TU Dresden

Sustainable Development Goals

ASJC Scopus subject areas


  • insulin, lipids, metabolism, regeneration, systemic response, Animals, Signal Transduction, Cicatrix/pathology, Wound Healing/physiology