The Covid-19 pandemic has adversely affected livelihoods in the Global South and exacerbated the effects of natural disaster. This study examines the ‘double strike’ of the Covid-19 lockdown and ‘super-cyclone’ Amphan on the 12 villages of Dakshin Bedkashi Union, southwest Bangladesh. It employs questionnaire surveys to assess the impact of the compound disaster on rural livelihoods over a period of five months, comparing pre-lockdown, post-lockdown, and post-Amphan phases. The results demonstrate the severe impact of the pandemic on income, occupation, and workdays, and consequently on livelihood resilience leading up to Amphan. Although effects vary moderately by livelihood category, village, and socio-spatial characteristics, overall rates of income reduction (58%) and occupation loss (77%) between the advent of the lockdown and the aftermath of Amphan are high. Thus, livelihood resilience to the double strike is generally poor. The study analyses the predictors of lost working days to illuminate the influences on livelihood resilience throughout the double strike. We conclude that the pandemic has presented novel challenges to this region, complicating vulnerability to more common cyclonic natural hazards. Finding that the degree of livelihood diversification is low in the sample, we recommend implementing diversification policies and strengthening local networks and community trust to better anticipate and combat the complex, varied impacts of double strike scenarios in future.