The “rolling contact related life calculation” (RCRL) of profiled rail guide systems takes the survival probability of every rolling contact into account, that allows a calculation of up to 4 times higher lifespans for pitch and yaw moments on a single guide. New calculation methods allow a user-friendly calculation of the RCRL, which differ from each other by the level of simplification and the computational effort. In this paper, they are summarized and compared to each other. With the temporary results of the experimental lifespan investigations, the applicability of the RCRL and the mathematical calculation methods can be confirmed. The mathematical models are based on an iterative calculation of the displacement between the wagon and the guide rail. Based on that, a concept for an indirect measurement of loads on the wagon is presented. Thereby a lifespan calculation at real operating conditions of the profiled rail guide system can be implemented.