Legionella und Legionellose

Research output: Contribution to journalResearch articleContributedpeer-review



Diagnosed and reported Legionella pneumonias are slightly increasing during recent years. This might at least partially be due to more frequently used diagnostic tests.In severe pneumonia, nucleic acid amplification based methods should supplement the L. pneumophila serogroup-1 urinary antigen test because of their improved spectrum and sensitivity.Recent in vitro data suggest enhanced efficacy of levofloxacin when compared to macrolides. This complements recent clinical cohort data. Thus levofloxacin (750-1000 mg/d) is regarded the treatment of choice for confirmed legionellosis. Second line options are azithromycin or moxifloxacin. Treatment duration of 7 days should be sufficient in most cases.Development of resistance is rare and no routine resistance testing is necessary.

Translated title of the contribution
Legionella and Legionellosis


Original languageGerman
Pages (from-to)1030-1033
Number of pages4
JournalDeutsche medizinische Wochenschrift (1946)
Issue number15
Publication statusPublished - Aug 2019

External IDs

ORCID /0000-0001-6022-6827/work/127321420
Scopus 85069809583



  • Anti-Bacterial Agents/pharmacology, Drug Resistance, Bacterial, Humans, Legionella/drug effects, Legionellosis/diagnosis, Levofloxacin/pharmacology