In machining, tool wear is one of the main influence factors for the resulting quality of the product. Several wear mechanisms have to be addressed to prevent unwanted deterioration of the tool integrity. For aluminium alloys, adhesion of the workpiece material on the cutting tool is one of the most challenging wear mechanisms. Engineering surface microtopographies has been proved as a convenient strategy to tackle this issue. Particularly, the direct laser interference patterning (DLIP) technique enables the integration of periodic structures on the micrometer or sub-micrometer scale. In this study the structuring of tungsten carbide with different cobalt content is presented. The interference of two laser beams leads to periodic line-like structures with a spatial period of 5.5 µm. A maximum structure depth of 2.2 µm is reached by controlling the processing parameters. Moreover, the wettability of the structured samples was analyzed by contact angle measurements with selected cooling lubricants, revealing a hydrophilic behavior with a decreased contact angle of 10°. This work gives an insight into the possibilities of structuring tungsten carbide materials with a picosecond laser source in combination with an innovative beam shaping setup from the point of view of an analysis to explore the formation of structured surfaces and their wetting behavior with cooling lubricants.