L1.1 is involved in spinal cord regeneration in adult zebrafish
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional [brelevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.
Details
Original language | English |
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Pages (from-to) | 7837-7842 |
Number of pages | 6 |
Journal | Journal of Neuroscience |
Volume | 24 |
Issue number | 36 |
Publication status | Published - 8 Sept 2004 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 15356195 |
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Keywords
ASJC Scopus subject areas
Keywords
- Brainstem, Cell recognition molecule, Danio rerio, Regeneration, Spinal cord, Teleost