Non-steroidal, anti-inflammatory drugs (NSAIDs, inhibitors of cyclooxygenases) are still worldwide the most intensively used remedies. These compounds are reliable therapeutics for muscle, joint, back, and traumatic pain. They cause, however, many unwanted side effects. Recently, the propensity of these compounds to cause cardiovascular diseases has been highlighted. As there are no alternatives available, attempts are made to single out those patients who are likely to develop unwanted cardiovascular drug effects when treated with NSAIDs. 2 widely used biomarkers were investigated as predictors of cardiovascular risks aggravated by the treatment with cyclooxygenase inhibitors. We here report on positive results of such evaluations employing the biomarker NTproBNP.