Iron-Catalyzed Cycloisomerization and C−C Bond Activation to Access Non-canonical Tricyclic Cyclobutanes

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Cycloisomerizations are powerful skeletal rearrangements that allow the construction of complex molecular architectures in an atom-economic way. We present here an unusual type of cyclopropyl enyne cycloisomerization that couples the process of a cycloisomerization with the activation of a C−C bond in cyclopropanes. A set of substituted non-canonical tricyclic cyclobutanes were synthesized under mild conditions using [(Ph3P)2Fe(CO)(NO)]BF4 as catalyst in good to excellent yields with high levels of stereocontrol.

Details

Original languageEnglish
Article numbere202205169
JournalAngewandte Chemie - International Edition
Volume61
Issue number38
Early online date12 Jul 2022
Publication statusPublished - 19 Sep 2022
Peer-reviewedYes

External IDs

PubMed 35818786
WOS 000837506000001
Mendeley e337355b-cf05-3e33-a8b4-fb97ecfecc5a

Keywords

DFG Classification of Subject Areas according to Review Boards

Subject groups, research areas, subject areas according to Destatis

ASJC Scopus subject areas

Keywords

  • Cyclobutanes, Cycloisomerization, Cyclopropanes, Iron Catalysis, Rearrangement, Iron, Catalysis, Cyclobutanes/chemistry, Cyclopropanes/chemistry