Iron effects versus metabolic alterations in hereditary hemochromatosis driven bone loss

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

Abstract

Hereditary hemochromatosis (HH) is a genetic disorder in which mutations affect systemic iron homeostasis. Most subtypes of HH result in low hepcidin levels and iron overload. Accumulation of iron in various tissues can lead to widespread organ damage and to various complications, including liver cirrhosis, arthritis, and diabetes. Osteoporosis is another frequent complication of HH, and the underlying mechanisms are poorly understood. Currently, it is unknown whether iron overload in HH directly damages bone or whether complications associated with HH, such as liver cirrhosis or hypogonadism, affect bone secondarily. This review summarizes current knowledge of bone metabolism in HH and highlights possible implications of metabolic dysfunction in HH-driven bone loss. We further discuss therapeutic considerations managing osteoporosis in HH.

Details

Original languageEnglish
Pages (from-to)652-663
Number of pages12
JournalTrends in Endocrinology and Metabolism
Volume33
Issue number9
Publication statusPublished - Sept 2022
Peer-reviewedYes

External IDs

Scopus 85134825540
unpaywall 10.1016/j.tem.2022.06.004
Mendeley fd27ab49-a7ed-3d0d-91e1-3253d137f4d5
WOS 000877913500005
ORCID /0000-0002-8691-8423/work/142236002

Keywords

Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards

Subject groups, research areas, subject areas according to Destatis

Sustainable Development Goals

Keywords

  • Hemochromatosis/complications, Humans, Iron/metabolism, Iron Overload/complications, Liver Cirrhosis/complications, Osteoporosis/genetics, endocrinopathies, hereditary hemochromatosis, iron, bone, osteoporosis, Mineral density, Hfe, Hepcidin promoter, Ferroportin, Idiopathic hemochromatosis, Osteoporosis, Soluble hemojuvelin, Overload, Gene, Transferrin receptor 2

Library keywords