Investigating human disease using stem cell models

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Jared L. Sterneckert - , Max Planck Institute for Molecular Biomedicine (Author)
  • Peter Reinhardt - , Max Planck Institute for Molecular Biomedicine (Author)
  • Hans R. Schöler - , Max Planck Institute for Molecular Biomedicine (Author)

Abstract

Tractable and accurate disease models are essential for understanding disease pathogenesis and for developing new therapeutics. As stem cells are capable of self-renewal and differentiation, they are ideally suited both for generating these models and for obtaining the large quantities of cells required for drug development and transplantation therapies. Although proof of principle for the use of adult stem cells and embryonic stem cells in disease modelling has been established, induced pluripotent stem cells (iPSCs) have demonstrated the greatest utility for modelling human diseases. Furthermore, combining gene editing with iPSCs enables the generation of models of genetically complex disorders.

Details

Original languageEnglish
Pages (from-to)625-639
Number of pages15
JournalNature Reviews Genetics
Volume15
Issue number9
Publication statusPublished - Sept 2014
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 25069490
ORCID /0000-0002-7688-3124/work/158767646

Keywords

Sustainable Development Goals