Intraoperative electron-beam therapy for primary and recurrent retroperitoneal soft-tissue sarcoma

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Robert Krempien - , Heidelberg University  (Author)
  • Falk Roeder - , Heidelberg University  (Author)
  • Susanne Oertel - , Heidelberg University  (Author)
  • Jürgen Weitz - , Heidelberg University  (Author)
  • Frank W. Hensley - , Heidelberg University  (Author)
  • Carmen Timke - , Heidelberg University  (Author)
  • Angela Funk - , Heidelberg University  (Author)
  • Katja Lindel - , Heidelberg University  (Author)
  • Wolfgang Harms - , Heidelberg University  (Author)
  • Markus W. Buchler - , Heidelberg University  (Author)
  • Jürgen Debus - , Heidelberg University  (Author)
  • Martina Treiber - , Heidelberg University  (Author)

Abstract

Purpose: This study assesses the long-term outcome of patients with retroperitoneal soft-tissue sarcomas treated by maximal resection in combination with intraoperative electron-beam therapy (IOERT) and postoperative external-beam radiotherapy. Methods and Materials: From 1991 to 2004, 67 patients were treated with curative intent for primary (n = 26) or recurrent (n = 41) retroperitoneal soft-tissue sarcoma. All patients underwent maximal resection in combination with IOERT (mean dose, 15 Gy), 45 patients underwent additional postoperative EBRT, and 20 patients were previously irradiated. Results: The 5-year actuarial overall survival (OS), disease-free survival, local control (LC), and freedom from metastatic disease of all patients was 64%, 28%, 40%, and 50%, respectively. The 5-year LC inside the IOERT field was 72%. For patients who completed IOERT and EBRT after R0-resection 5-year and 10-year OS was 80%, and 5-year and 10-year LC was 100%. Only 1 of the 21 patients after R0-resection and only 8 of 34 patients after R1-resection compared with 9 of 12 patients after R2-resection experienced inside IOERT-field relapse. Grade II or higher late complications were seen in 21% of the patients, but only 2 patients required surgical intervention because of late complications. Conclusion: In selected patients, IOERT results in excellent local control and survival, with acceptable morbidity.

Details

Original languageEnglish
Pages (from-to)773-779
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume65
Issue number3
Publication statusPublished - 1 Jul 2006
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 16682152

Keywords

Sustainable Development Goals

Keywords

  • Intraoperative radiotherapy, Local control, Radiotherapy, Retroperitoneal sarcoma, Soft-tissue sarcoma