The continuous advances in micro- and nanofabrication technologies have inevitably led to major improvements in field-effect transistor (FET) design and architecture, significantly reducing the component footprint and enabling highly efficient integration into many electronic devices. Combined efforts in the areas of materials science, life sciences, and electronic engineering have unlocked opportunities to create ultrasensitive FET chemo- and biosensor devices that are coupled with more diverse and complex integration requirements in terms of hardware interfacing, reproducible functionality, and handling of analyte samples. Integration of FET chemo- and biosensors remains one of the major bottlenecks in bridging the gap between fundamental research concepts and commercial sensing devices. In this review, we critically discuss different strategies and formats of integration in the context of key requirements, fabrication scalability, and device complexity. The intentions of this review are 1) to provide a practical overview of successful FET sensor integration approaches, 2) to identify crucial challenges and factors limiting the extent of FET sensor integration, and 3) to highlight promising perspectives for future developments of FET sensor integration. We believe that our structured insights will be helpful for scientists and engineers of various profiles focusing on the design and development of FET-based chemo- and biosensor devices.