Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Lydia Kalafati; Ioannis Kourtzelis; Jonas Schulte-Schrepping; Xiaofei Li; Aikaterini Hatzioannou; Tatyana Grinenko; Eman Hagag; Anupam Sinha; Canan Has; Sevina Dietz; Antonio Miguel de Jesus Domingues; Marina Nati; Sundary Sormendi; Ales Neuwirth; Antonios Chatzigeorgiou; Athanasios Ziogas; Mathias Lesche; Andreas Dahl; Ian Henry; Pallavi Subramanian; Ben Wielockx; Peter Murray; Peter Mirtschink; Kyoung Jin Chung; Joachim L. Schultze; Mihai G. Netea; George Hajishengallis; Panayotis Verginis; Ioannis Mitroulis; Triantafyllos Chavakis

doi:10.1016/j.cell.2020.09.058

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

Lydia Kalafati - , Institute of Clinical Chemistry and Laboratory Medicine, National Center for Tumor Diseases Dresden, University Hospital Carl Gustav Carus Dresden, German Cancer Research Center (DKFZ) (Joint first author)
Ioannis Kourtzelis - , TUD Dresden University of Technology, German Cancer Research Center (DKFZ), University of York (Joint first author)
Jonas Schulte-Schrepping - , University of Bonn (Author)
Xiaofei Li - , University of Pennsylvania (Author)
Aikaterini Hatzioannou - , Academy of Athens (Author)
Tatyana Grinenko - , Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden (Author)
Eman Hagag - , Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden (Author)
Anupam Sinha - , Institute of Clinical Chemistry and Laboratory Medicine, National Center for Tumor Diseases Dresden, University Hospital Carl Gustav Carus Dresden, German Cancer Research Center (DKFZ) (Author)
Canan Has - , TUD Dresden University of Technology (Author)
Sevina Dietz - , TUD Dresden University of Technology (Author)
Antonio Miguel de Jesus Domingues - , Max Planck Institute of Molecular Cell Biology and Genetics (Author)
Marina Nati - , Dresden International Graduate School for Interdisciplinary Life Sciences (DIGS-ILS), Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden (Author)
Sundary Sormendi - , TUD Dresden University of Technology (Author)
Ales Neuwirth - , TUD Dresden University of Technology (Author)
Antonios Chatzigeorgiou - , TUD Dresden University of Technology (Author)
Athanasios Ziogas - , TUD Dresden University of Technology (Author)
Mathias Lesche - , DRESDEN-concept Genome Center (CMCB Core Facility) (Author)
Andreas Dahl - , DRESDEN-concept Genome Center (CMCB Core Facility) (Author)
Ian Henry - , Max Planck Institute of Molecular Cell Biology and Genetics (Author)
Pallavi Subramanian - , Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden (Author)
Ben Wielockx - , Institute of Clinical Chemistry and Laboratory Medicine (Author)
Peter Murray - , Max Planck Institute of Biochemistry (Author)
Peter Mirtschink - , Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden (Author)
Kyoung Jin Chung - , Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden (Author)
Joachim L. Schultze - , University of Bonn, German Center for Neurodegenerative Diseases (DZNE) (Author)
Mihai G. Netea - , University of Bonn, Radboud University Nijmegen (Author)
George Hajishengallis - , University of Pennsylvania (Author)
Panayotis Verginis - , TUD Dresden University of Technology, Academy of Athens (Author)
Ioannis Mitroulis - , Institute of Clinical Chemistry and Laboratory Medicine, National Center for Tumor Diseases Dresden, University Hospital Carl Gustav Carus Dresden, German Cancer Research Center (DKFZ) (Author)
Triantafyllos Chavakis - , Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden, University of Edinburgh (Author)

Abstract

Pre-treatment of mice with β-glucan, an agonist of trained immunity responses, leads to epigenetic changes in granulopoiesis and neutrophil function to drive anti-tumor immune responses.

Details

Original language	English
Pages (from-to)	771-785.e12
Journal	Cell
Volume	183
Issue number	3
Publication status	Published - 29 Oct 2020
Peer-reviewed	Yes

External IDs

PubMed	33125892
ORCID	/0000-0002-3274-7163/work/142249703
ORCID	/0000-0002-4923-2596/work/211722304

Keywords

Sustainable Development Goals

SDG 3 - Good Health and Well-being

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

Keywords

cancer immunotherapy, granulopoiesis, inflammation, innate immune memory, interferon, neutrophils, trained immunity, β-glucan

Library keywords

610 Medicine and health

Research Portal of the TU Dresden

Contributors

Abstract

Details

External IDs

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

Library keywords