Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy.

Details

Original languageEnglish
Article numbere003109
JournalBMJ Paediatrics Open
Volume9
Issue number1
Publication statusPublished - 7 Jan 2025
Peer-reviewedYes

Keywords

Sustainable Development Goals

Keywords

  • COVID-19, Neonatology