Inferring synaptic connectivity from spatio-temporal spike patterns

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Frank Van Bussel - , Max Planck Institute for Dynamics and Self-Organization, University of Göttingen, Bernstein Center for Computational Neuroscience Göttingen (Author)
  • Birgit Kriener - , Max Planck Institute for Dynamics and Self-Organization, University of Göttingen, Norwegian University of Life Sciences (Author)
  • Marc Timme - , Max Planck Institute for Dynamics and Self-Organization, University of Göttingen, Bernstein Center for Computational Neuroscience Göttingen (Author)

Abstract

Networks of well-known dynamical units but unknown interaction topology arise across various fields of biology, including genetics, ecology, and neuroscience. The collective dynamics of such networks is often sensitive to the presence (or absence) of individual interactions, but there is usually no direct way to probe for their existence. Here we present an explicit method for reconstructing interaction networks of leaky integrate-and-fire neurons from the spike patterns they exhibit in response to external driving. Given the dynamical parameters are known, the approach works well for networks in simple collective states but is also applicable to networks exhibiting complex spatio-temporal spike patterns. In particular, stationarity of spiking time series is not required.

Details

Original languageEnglish
Article number3
JournalFrontiers in computational neuroscience
Volume5
Publication statusPublished - 1 Feb 2011
Peer-reviewedYes
Externally publishedYes

External IDs

ORCID /0000-0002-5956-3137/work/142242493

Keywords

Keywords

  • Chaotic spiking, Inverse methods, Irregular spiking, Leaky integrate-and-fire neuron, Networks, Synchronization