In situ study of the thermoresponsive behavior of micropatterned hydrogel films by imaging ellipsometry

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Dirk Schmaljohann - , Welsh School of Pharmacy, Cardiff University & Cardiff Institute of Tissue Engineering and Repair (CITER), Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, Wales, U.K. dchmaljohannd@cf.ac.uk (Author)
  • Mirko Nitschke - (Author)
  • Roland Schulze - (Author)
  • Andreas Eing - (Author)
  • Carsten Werner - , Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden (Author)
  • Klaus-Jochen Eichhorn - (Author)

Abstract

A patterned hydrogel was immobilized on a polymer substrate by low-pressure argon plasma treatment using a masking technique. The polymer sample showed a thermoresponsive aggregation behavior in the region of 35-37 degrees C. The micropatterned, thermoresponsive hydrogel film has been characterized with imaging ellipsometry. The characterization was carried out on the dry film as well as on a swollen sample in water. The thermoresponsive behavior was studied in deionized water by temperature-dependent measurements in a solid-liquid cell. Through imaging ellipsometry, it was possible to distinguish the different regions of interest on a micrometer scale and to follow the swelling of the hydrogel part as a function of the temperature. It was possible to visualize the swelling as 3D profiles of Delta at various temperatures. Long-term changes of the sample could also be detected, which cannot be picked up by conventional ellipsometry.

Details

Original languageEnglish
Pages (from-to)2317-22
Number of pages6
JournalLangmuir
Volume21
Issue number6
Publication statusPublished - 15 Mar 2005
Peer-reviewedYes
Externally publishedYes

External IDs

Scopus 15844396842
ORCID /0000-0003-0189-3448/work/173985723

Keywords