In silico study of vessel and stent-graft parameters on the potential success of endovascular aneurysm repair
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
The variety of stent-graft (SG) design variables (eg, SG type and degree of SG oversizing) and the complexity of decision making whether a patient is suitable for endovascular aneurysm repair (EVAR) raise the need for the development of predictive tools to assist clinicians in the preinterventional planning phase. Recently, some in silico EVAR methods have been developed to predict the deployed SG configuration. However, only few studies investigated how to assess the in silico EVAR outcome with respect to EVAR complication likelihoods (eg, endoleaks and SG migration). Based on a large literature study, in this contribution, 20 mechanical and geometrical parameters (eg, SG drag force and SG fixation force) are defined to evaluate the quality of the in silico EVAR outcome. For a cohort of n = 146 realizations of parameterized vessel and SG geometries, the in silico EVAR results are studied with respect to these mechanical and geometrical parameters. All degrees of SG oversizing in the range between 5% and 40% are investigated continuously by a computationally efficient parameter continuation approach. The in silico investigations have shown that the mechanical and geometrical parameters are able to indicate candidates at high risk of postinterventional complications. Hence, this study provides the basis for the development of a simulation-based metric to assess the potential success of EVAR based on engineering parameters.
Details
Original language | English |
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Article number | e3237 |
Journal | International journal for numerical methods in biomedical engineering |
Volume | 35 |
Issue number | 11 |
Publication status | Published - 1 Nov 2019 |
Peer-reviewed | Yes |
External IDs
PubMed | 31315160 |
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Keywords
ASJC Scopus subject areas
Keywords
- abdominal aortic aneurysm, endovascular repair, hostile neck, oversizing, stent-graft