The global elderly population rises, increasing dementia cases. Built environment impact on dementia health outcomes is known, forming the basis for evidence-based design studies. There's a need for a comprehensive assessment framework due to the complexity of interactions among Architectural Variables (AVs) and Health and Care Outcomes (HCOs). This paper proposes using Model-Based Systems Engineering (MBSE) to create such a framework. It collects data from 105 studies on 40 AVs, 36 HCOs, and 396 interactions. MBSE offers a holistic understanding, aiding healthcare facility design decisions.